Fri Feb 25 2022

94 articles - From Saturday Feb 19 2022 to Friday Feb 25 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…

Clin Gastroenterol Hepatol

International consensus recommendations for eosinophilic gastrointestinal disease nomenclature.

This international process resulted in consensus for updated EGID nomenclature for both clinical and research use. EGID will be the umbrella term rather than "eosinophilic gastroenteritis", and specific naming conventions by location of GI tract involvement are recommended. As more data are developed, this framework can be updated to reflect best practices and the underlying science.

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IOIBD Recommendations for Clinical Trials in Ulcerative Proctitis: the PROCTRIAL Consensus.

In response to the need for guidance on the design of clinical trials in patients with ulcerative proctitis, the PROCTRIAL consensus provides recommendations on the definition and endpoints for ulcerative proctitis clinical trials.

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Endoscopy

Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.

Strong recommendation, low quality evidence. 10: For lower or upper GI NEN with a positive or indeterminate margin at resection, ESGE recommends repeating endoscopy at 3-6 months and another attempt at endoscopic resection in the case of residual disease. Strong recommendation, low quality evidence.

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Gastroenterology

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review.

BEST PRACTICE ADVICE 10: The decision to discontinue PPIs should be based solely on the lack of an indication for PPI use, and not because of concern for PAAEs. The presence of a PAAE or a history of a PAAE in a current PPI user is not an independent indication for PPI withdrawal. Similarly, the presence of underlying risk factors for the development of an adverse event associated with PPI use should also not be an independent indication for PPI withdrawal.

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Gastrointest Endosc

American Society for Gastrointestinal Endoscopy guideline on screening for pancreatic cancer in individuals with genetic susceptibility: methodology and review of evidence.

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ASGE guideline on screening for pancreatic cancer in individuals with genetic susceptibility: summary and recommendations.

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Systematic review: non-endoscopic surveillance for colorectal neoplasia in individuals with Lynch syndrome.

Imaging techniques are unsuitable for colon surveillance in Lynch syndrome, whereas biomarkers are understudied. Having outlined biomarker research in Lynch-associated and sporadic CRC/adenomas, we believe that these non-invasive markers may hold potential (whether or not combined) for this population. As they could be of great value, (pre-)clinical studies in this field should be prioritised.

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Clin Gastroenterol Hepatol

Effectiveness and Durability of COVID-19 Vaccination in 9447 Patients with IBD: A Systematic Review and Meta-Analysis.

Complete COVID-19 vaccination is associated with seroconversion in most patients with IBD. The decay in titers over time necessitates consideration of additional doses in these patients.

Pubmed   Journal   ReadQx   PMC

UNOS Down-staging Criteria for Liver Transplantation of Hepatocellular Carcinoma: Systematic Review and Meta-Analysis of 25 Studies.

Among patients that received LT, 16.01% (11.80 - 21.37) developed HCC recurrence. Comparing studies that utilized the United Network for Organ Sharing Down-staging (UNOS-DS) criteria versus studies beyond UNOS-DS or did not specify criteria, down-staging success (by ITT) was 83.21% versus 45.93%, p 50% received LT and post-LT outcomes were excellent. These data provide clinical validation for the utilization of UNOS-DS criteria.

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Hepatology

Genome-wide Meta-analysis Identifies Novel Susceptibility Loci for Autoimmune Hepatitis Type 1.

Our study identifies two novel loci (CD28-CTLA4-ICOS and SYNPR) exceeding genome-wide significance and suggests four loci as potential risk factors. These findings highlight the importance of co-stimulatory signaling and neuro-immune interaction in the pathogenesis of AIH.

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Inflamm Bowel Dis

The Magnitude of Crohn's Disease Direct Costs in Health Care Systems (from Different Perspectives): A Systematic Review.

Our review highlighted the burden of CD for health care systems from different perspectives (regional, economic, and temporal) and analyzed the impact of the change of IBD treatment paradigm on total costs. Reducing the overall burden can depend on the increase of remission rates to further decrease hospitalizations and surgeries.

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J Neurogastroenterol Motil

Functional neuroimaging in Irritable Bowel Syndrome: a systematic review highlights common brain alterations with Functional Movement Disorders.

Moreover, glutamatergic dysfunction in the anterior insula and hypothalamic pituitary axis dysregulation were often reported. These alterations seem to be very similar to those observed in patients with functional movement disorders. Hence, we speculate that different functional disturbances might share a common pathophysiology and we discussed our findings in the light of a Bayesian model framework.

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Studies

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Clinical outcome of infantile-onset inflammatory bowel disease in 102 patients with interleukin-10 signalling deficiency.

The survival probability was not significantly different between patients with transplantation and the non-transplanted patients.

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Delayed gastric emptying as an independent predictor of mortality in gastroparesis.

This study has shown that gastroparesis, diagnosed on GE tests, was associated with increased mortality, independently of age, sex, BMI or diabetes status (NCT04918329).

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Am J Gastroenterol

Endoscopic papillary large balloon dilation reduces further recurrence in patients with recurrent common bile duct stones: a randomized controlled trial: EPLBD reduces further recurrence of CBD stones.

During long-term follow-up, nearly half of patients with recurrent CBDS experienced stone recurrence after traditional ERCP. Our study was the first to show that EPLBD effectively reduced the recurrence of CBDS.

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Hepatitis B Core-related Antigen Stratifies the Risk of Liver Cancer in HBeAg-negative Patients with Indeterminate Phase.

Serum HBcrAg level of 10,000 U/mL stratifies HCC risk in HBeAg-negative patients with indeterminate phase, which is useful for optimizing their clinical management.

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Clin Gastroenterol Hepatol

Discrete choice experiment reveals strong preference for dietary treatment among patients with irritable bowel syndrome.

Dietary interventions were the most-preferred IBS therapy. Identifying patients' treatment preferences during shared decision-making, will provide more optimal management strategies and could be the best approach to diminish disease burden.

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Factors impacting survival in those transplanted for NASH cirrhosis: Data from the NailNASH Consortium.

Despite excellent long-term survival, patients transplanted for NASH at >65 years or with type 2 DM at transplant had higher mortality. Statin use post-transplant attenuated risk and was associated with improved survival across al subgroups suggesting that careful patient selection and implementation of protocol-based management of metabolic co-morbidities may further improve clinical outcomes.

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Fluticasone Propionate Orally Disintegrating Tablet (APT-1011) for Eosinophilic Esophagitis: Randomized Controlled Trial.

APT-1011 dosing regimens were superior for histologic and endoscopic responses, and for reduction in dysphagia frequency vs placebo. Based on the symptom improvement and assessment of adverse events together with the histologic response rate, 3mg once daily at bedtime dose showed the most favorable risk-benefit profile. ClinicalTrials.gov, number NCT03191864.

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Image enhanced endoscopy and molecular biomarkers vs Seattle protocol to diagnose dysplasia in Barrett's esophagus.

Seattle protocol biopsies miss dysplasia in approximately half of patients with inconspicuous neoplasia. AFI-guided pCLE has similar accuracy to the current gold standard. Addition of molecular biomarkers could improve diagnostic accuracy.

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Endoscopy

Impact of transmural plastic stent on recurrence of pancreatic fluid collection after metal stent removal in disconnected pancreatic duct: a randomized controlled trial.

In patients with WON and DPD, deployment of plastic stents after LCMS removal did not reduce recurrence of PFC.

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Gastrointest Endosc

Analysis of Reported Adverse Events Related to Single Use Duodenoscopes and Duodenoscopes with Detachable Endcaps.

Findings from the MAUDE database highlight patient and device complications that endoscopists should be aware of in using single-use duodenoscopes and duodenoscopes with detachable caps. While these devices mitigate infection transmission risk, they are associated with additional device-associated adverse events.

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Endoscopic eradication therapy for Barrett's Esophagus related neoplasia. A final 10 year report from the United Kingdom National Halo Radiofrequency Ablation Registry.

RFA treatment is effective and durable to prevent esophageal adenocarcinoma. Most treatment relapses occur early and can be successfully retreated.

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Reproducibility of the electronic chromoendoscopy PICaSSO score (Paddington International Virtual ChromoendoScopy ScOre) in Ulcerative Colitis using multiple endoscopic platforms: A prospective multicenter international study.

PICaSSO score can be consistently and accurately reproduced with NBI and LCI/BLI, and therefore can be applied to al VCE platforms.

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Risk of total metachronous advanced neoplasia in patients with both small tubular adenomas and serrated polyps.

When small TAs are found concomitantly with small SPs, there is an increase in the rate of T-MAN in comparison to isolated tubular adenomas. This increase in T-MAN also occurs when small TAs are found in conjunction with small proximal HPs. The presence of concomitant small SPs should be considered in determining surveillance intervals when small TAs are identified in colonoscopy screening programs.

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Technical Feasibility of Salvage Endoscopic Submucosal Dissection after Chemoradiation for Locally Advanced Rectal Adenocarcinoma.

Salvage ESD for locally advanced rectal cancer is technically feasible and with low adverse event rates. There may be a diagnostic role in salvage ESD in assessing pathological response to CRT, as well as a possibly therapeutic role in resection of residual lesions with the potential to avoid surgery.

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Gut

Inflamed and non-inflamed classes of HCC: a revised immunogenomic classification.

A 20-gene signature was able to capture ~90% of these tumours and is associated with response to immunotherapy. Proteins identified in liquid biopsies recapitulated the inflamed class with an area under the ROC curve (AUC) of 0.91; (2) The intermediate class, enriched in patterns associated with a differential role in immune evasion are described. These features may help predict immune response in HCC.

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Hepatology

A Developmentally Prometastatic Niche to Hepatoblastoma in Neonatal Liver mediated by the Cxcl1/Cxcr2 Axis.

We demonstrated that the neonatal liver provides a prometastatic niche to HB development via the Cxcl1/Cxcr2 axis.

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Changes in serum hepatitis B surface and e antigen, IP-10, and aminotransferase levels during combination therapy of immune tolerant chronic hepatitis B.

Induction of IP-10 during peginterferon treatment in adults and children in the IT phase of chronic HBV infection is associated with ALT elevations and decline in viral antigens suggesting a degree of interferon-inducible viral control.

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Dynamic risk profiling of hepatocellular carcinoma recurrence after curative intent liver resection.

In contrast to standard single time-to-event estimates, multistate modeling provides more realistic prognostication of outcomes after LR for HCC by taking into account many postoperative disease states and transitions between them. Our multistate modeling calculator can provide meaningful data to guide the management of patients undergoing postoperative surveillance and therapy.

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Hypoxia-driven immunosuppression by Treg and type-2 conventional dendritic cells in hepatocellular carcinoma.

We uncovered the unique immunosuppressive landscapes and identified key immune subsets enriched in hypoxic HCC. In particular, we identified a potential Treg-mediated immunosuppression through interaction with cDC2 subset in HCC that could be exploited for novel immunotherapies.

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Inflamm Bowel Dis

A Mixed-methods Assessment of the Impact of Insurance Issues on the Emotional and Physical Health of Patients With Inflammatory Bowel Disease.

A large proportion of our cohort chose not to inform their provider, felt incapable of managing on their own, and gave up on resolving their insurance issue. This highlights the need to consider restructuring the insurance system, to identify those at risk for insurance issues, and to make advocates available to avoid devastating consequences.

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Early Pouchitis Is Associated With Crohn's Disease-like Pouch Inflammation in Patients With Ulcerative Colitis.

Early pouchitis is significantly associated with subsequent CDLPI development and may be the first indication of enhanced mucosal immune activation in the pouch.

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Neurogastroenterol Motil

Solid bolus swallows during high-resolution manometry complement multiple rapid swallows in predicting symptoms following antireflux surgery.

Multiple rapid swallows and SBS are complementary in predicting post-ARS symptom burden.

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White-matter microstructural alterations in patients with functional constipation: A tract-based spatial statistics study.

These WM tracts are mainly responsible for sensory and emotional information communication and corresponding functional integration; thus, our findings indicate an association between FC and WM microstructural abnormalities in regions involved with visceral afferent and emotional-arousal processing. Alterations in WM microstructures including the CC, cingulum, and ACR are more related to psychological symptoms than constipation, which might have greater impact on brain structures.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Review article: post-TIPSS hepatic encephalopathy-current knowledge and future perspectives.

Careful selection of TIPSS candidates is of utmost importance to reduce the risk of post-TIPSS HE. In this narrative review, we provide a concise overview of the current epidemiology and risk factors of the treatment options for post-TIPSS HE.

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Review: switching patients with chronic hepatitis B to tenofovir alafenamide-a review of current data.

Switching to TAF appears to maintain or improve virological, biochemical and bone- and renal-related safety outcomes. These data support the concept of switching to TAF in some patients with CHB based on their individual circumstances.

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Clin Gastroenterol Hepatol

Bridging the gap: Screening for non-alcoholic fatty liver disease in the primary care population.

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New-Onset Diabetes as a Signpost of Early Pancreatic Cancer: The Role of Screening.

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Postoperative Crohn's disease recurrence: time to adapt endoscopic recurrence scores to the leading surgical techniques.

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Gastrointest Endosc

Can artificial intelligence be your angel to diagnose early gastric cancer in real clinical practice?

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Real-time use of artificial intelligence at colonoscopy predicts relapse in ulcerative colitis: predicting with "intelligence".

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The importance of harmonizing pancreatic EUS findings.

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What can therapeutic endoscopists learn from the use of electrosurgery in papillectomy?

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Hepatology

Autoimmune hepatitis in pregnancy: pearls and pitfalls.

Population studies, report improved outcomes with preterm birth rates falling from 20% to 9-13% in AIH pregnancies over a 20-year period. Newer data have also demonstrated an increased risk of gestational diabetes and hypertensive complications in AIH pregnancy which has implications for management and pre-eclampsia prevention with aspirin use. This review aims to provide the framework to guide and manage pregnancy in AIH outlining pearls and pitfalls to ensure optimal outcomes for mother, baby and to reduce variation in practice.

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Fontan Associated Liver Disease.

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Implementation Science: accelerating translation of clinical evidence into practice.

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Inflamm Bowel Dis

SARS-CoV-2 Infection in the Follow-Up of a Population With Inflammatory Bowel Disease.

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J Neurogastroenterol Motil

Clinical trials of probiotics in patients with IBS - some points to consider.

How can they tell which products truly are what they claim to be? Which probiotics should be chosen for a particular clinical situation? These questions are thrown into stark relief when one evaluates the literature on probiotics in irritable bowel syndrome. To provide some guidance the current probiotic landscape is reviewed and some achievable steps to help bring light to a murky environment are proposed. The goal is to promote verifiable quality control and generate actionable evidence from well-conducted clinical trials of probiotic products in irritable bowel syndrome.

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Pathophysiological Commonality Between Irritable Bowel Syndrome and Metabolic Syndrome: Role of Corticotropin-releasing Factor-Toll-like Receptor 4-Proinflammatory Cytokine Signaling.

This review discusses the potential mechanisms of IBS and MS with reference to gut barrier and microbiota, and explores the possibility of existence of pathophysiological link between these diseases with a focus on CRF, TLR4, and proinflammatory cytokine signaling. We also review epidemiological data supporting this possibility, and discuss the potential of therapeutic application of the drugs used for MS to IBS treatment. This notion may pave the way for exploring novel therapeutic approaches for these disorders.

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Letters&Replies

Letters to the editors and authors’ replies

Gastroenterology

Reply: Letter to the Editor: INTESTINAL MICROBIOME MODULATION DURING COVID-19: ANOTHER CHANCE TO MANAGE THE DISEASE?

Pubmed   Journal   ReadQx   PMC

Response to Sullivan et al.

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Gastrointest Endosc

Prophylactic antibiotics for postendoscopic submucosal dissection coagulation syndrome.

Pubmed   Journal   ReadQx 

R0 resection rates with underwater EMR better than conventional EMR: an updated analysis.

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Gut

Comment on Murphy et al: maternal obesity, pregnancy weight gain, and birth weight and risk of colorectal cancer.

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Hepatology

Letter to the Editor: Association Between Proton Pump Inhibitor Use and Biliary Tract Cancer Risk: A Swedish Population-Based Cohort Study.

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J Hepatol

Management of portal hypertension in patients treated with Atezolizumab and Bevacizumab for hepatocellular carcinoma.

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Others

all remaining publications eg case reports, images of the month, etc…

Am J Gastroenterol

Catching Jaws: Migrated Over-the-Scope Clip Resulting in Capture of Intravascular Coils.

Pubmed   Journal   ReadQx 

Link Between Obesity and Early-Onset Colorectal Cancers (EOCRC): Importance of Accounting for BMI Trajectories in Early Life.

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Clin Gastroenterol Hepatol

An evaluation of online cirrhosis-related information intended for patients and caregivers.

Pubmed   Journal   ReadQx 

Comparable efficacy between ongoing versus initiation of antiviral therapy at treatment for HBV-related hepatocellular carcinoma.

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Fully Covered Self-Expanding Stents are Cost-Effective at Remediating Biliary Strictures in Patients with Chronic Pancreatitis.

Pubmed   Journal   ReadQx 

Long-term effect of PNPLA3 on the aggravation of nonalcoholic fatty liver disease in the biopsy-proven cohort.

Pubmed   Journal   ReadQx 

Long-term follow-up of hepatitis C patients who achieved sustained virologic response in the pragmatic PRIORITIZE Study.

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Performance of Vibration Controlled Transient Elastography and Clinical Prediction Models In Liver Transplant Recipients.

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Role of Hepatitis B Surface Antibodies in Risk for Hepatitis B Virus Reactivation During Anti-Tumor Necrosis Factor Therapy.

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Endoscopy

A homemade endoscopic guillotine strikes again: removal of a nasogastric tube mysteriously knotted in the proximal third of the esophagus.

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Clip-induced esophageal perforation during endoscopic submucosal dissection: the perfect is the enemy of the good!

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Combined endoscopic and surgical management of a right intrahepatic bile duct injury during laparoscopic cholecystectomy.

Pubmed   Journal   ReadQx 

Effective use of image-enhanced endoscopy and endoscopic submucosal dissection for multiple flat non-polypoid colorectal neoplasms.

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Endoscopic percutaneous drainage in a COVID-19 patient with iatrogenic gastric perforation.

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Endoscopic ultrasound-directed transgastric ERCP: esophageal stent to the rescue.

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Is endoscopic mucosal resection optimum for treating colonic angiodysplasia?

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Mucosal defect closure using a calibrated, small-caliber-tip, transparent hood after colorectal endoscopic submucosal dissection.

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Perforation of the greater gastric curvature by a gastric adenocarcinoma with engulfment of the upper pole of the spleen.

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Preemptive clipping for post-ampullectomy bleeding: the jury is still out.

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Traction-assisted circumferential endoscopic submucosal dissection of early esophageal squamous cell carcinoma, followed by metal stent insertion and fixation with a dedicated clip.

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Gastroenterology

An unusual cause of Gastric outlet obstruction (GOO).

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Comparable results of Helicobacter pylori Antibiotic Resistance Testing of Stools versus Gastric Biopsies using Next Generation Sequencing.

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DEVELOPMENT OF PRODUCTS TO PROMOTE BOWEL CLEANSING FOR COLONOSCOPY-DRAFT GUIDANCE FROM THE UNITED STATES FOOD AND DRUG ADMINISTRATION.

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Green endoscopy: counting the carbon cost of our practice.

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How to integrate artificial intelligence in gastrointestinal practice.

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Optimizing Value for Colorectal Cancer Screening in Medicare Accountable Care Organizations.

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Gastrointest Endosc

Artificial intelligence-assisted detection of colorectal polyps in Lynch syndrome.

Pubmed   Journal   ReadQx 

Texture and Color Enhancement Imaging combination with indigo carmine dye spraying highlighted the border of flat ulcerative colitis-associated neoplasia.

Pubmed   Journal   ReadQx 

Use of a novel telemetric capsule for detection of large bowel bleeding caused by angioectasias.

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Gut

Real-life multicentre study of lumen-apposing metal stent for EUS-guided drainage of pancreatic fluid collections.

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Toxic trail from the gut to the brain.

Pubmed   Journal   ReadQx 

Hepatology

In Memoriam: John R. Senior 1928 - 2022.

Pubmed   Journal   ReadQx 

Inflamm Bowel Dis

Antibiotic Use Patterns in the Management of Chronic Pouchitis.

Pubmed   Journal   ReadQx 

Cap-Polyposis: A Cause of Treatment Failure in Ulcerative Colitis.

Pubmed   Journal   ReadQx 

Reply to Antibiotic Use Patterns in the Management of Chronic Pouchitis.

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J Crohns Colitis

You Are What You Eat? Growing Evidence That Diet Influences the Risk of Inflammatory Bowel Disease.

Pubmed   Journal   ReadQx 

J Hepatol

Expression of concern: "The risk-benefit assessment of liver biopsy in times of non-invasive screening for liver fibrosis" by Ivana Ilic and Tamara Milovanovic [J Hepatol 73 (2020) 701-702].

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